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Schwannomas are mostly benign tumors that most commonly occur in those with NF2 and Schwannomatosis. Schwann cells are glial cells that coat of nerve cells of the brain, spine and peripheral nerves. When Schwann cells reproduce at an unregulated rate it is called known as Schwannoma.

Despite being benign, Schwannomas can cause impairments when they begin to increase pressure on nerves in the brain and spine. About ⅓ of patients with Schwannomatosis will only have tumors in a single area of the body. Many of the symptoms of Schwannomatosis are similar to the symptoms seen in NF2. Symptoms are sometimes a result of hormonal changes, puberty or pregnancy.

Those suffering with Schwannomatosis can experience signs or symptoms including:
● Headache
● Pain in the back or neck
● Pain in the extremities (radiculopathy)
● Numbness or tingling in the extremities